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A collaborative effort by Helmholtz Munich, the German Diabetes Center, and the German Center for Diabetes Research

Obesity: An Overview

Scientific support: Prof. Dr. Christina Holzapfel

Obesity (severe overweight) is a chronic disease. It is based on an excessive increase in body fat due to a long-term positive energy balance. This means that more energy (kilocalories) is taken in through food than is consumed through metabolism and physical activity. The excess energy is stored in the body in the form of fat deposits. Numerous genetic, biological, psychological and socio-economic factors – such as income and education – as well as lifestyle and environmental factors contribute to the development of obesity.

Obesity can have a negative impact on well-being and quality of life and is associated with an increased risk of developing concomitant and secondary diseases. It requires comprehensive and lifelong treatment. The treatment is based on nutrition, exercise and behavioral therapy. In addition, formula diets and drugs can be used as support. Surgical intervention can also be useful in some cases. Digital tools such as apps and pedometers and what are called digital health applications (DiGAs; apps on prescription) support weight reduction.

A healthy lifestyle with a balanced diet, regular exercise, little stress and sufficient sleep can prevent the development of overweight and obesity.

Like diabetes and cardiovascular diseases, obesity is a non-communicable disease.

On this page you will find the most important information about obesity at a glance.



1. Clinical picture of obesity

Obesity is a chronic disease recognized by the World Health Organization (WHO) and the German Bundestag. Obesity is also a risk factor for numerous concomitant and secondary diseases such as restricted mobility, type 2 diabetes, cardiovascular diseases and breathing disorders during sleep (sleep apnea syndrome).

There are many causes of obesity: Genetic predisposition, a high-calorie diet, lack of exercise, stress and lack of sleep all play a role, as do socio-economic (education, income and occupation), psychological and environmental factors. Once stored, fat reserves are difficult to break down again and require comprehensive and lifelong therapy – individually adapted and under specialist care.

The earlier obesity is recognized and treated, the better the chances of reducing body weight, preventing concomitant and secondary diseases and thus improving health, quality of life and well-being.

Find further information on the development and clinical picture of obesity here.
 

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2. What concomitant and secondary diseases can be associated with obesity?

Obesity increases the risk of a number of concomitant and secondary diseases that affect the entire body. These include, for example:

Abdominal obesity in particular, where fat accumulates in the abdomen, is associated with an increased health risk. In addition, the risk increases with the severity and duration of obesity. And genetic predisposition also affects the individual risk.

In addition to physical complaints, obesity is often associated with a reduced quality of life and psychosocial consequences such as stigmatization, depression and/or anxiety disorders.

Find more information on the various concomitant and secondary diseases of obesity here.
 

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3. What can I do to prevent obesity?

The risk of developing overweight and obesity can be reduced by several measures. To achieve this, lifestyle plays a decisive role. A balanced diet, plenty of exercise, little stress and sufficient sleep are the most important factors in keeping body weight within the normal range and avoiding secondary diseases.

The diet should be as varied as possible and adapted to individual needs. There are various suitable forms of nutrition. It is also important to avoid highly processed foods and sugar-sweetened drinks.

The World Health Organization (WHO) recommends a combination of endurance and strength training as physical activity, as well as balance and coordination exercises for people aged 65 and over. In addition, as much exercise as possible should be integrated into everyday life and sitting times should be reduced.

It is important to avoid stress and get enough sleep with a regular sleep pattern.

Find more information about what you can do to prevent overweight and obesity here.
 

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4. How high is my risk and how is obesity diagnosed?

The risk of developing obesity is increased by a variety of factors, some of which can be controlled to a greater and some to a lesser extent. Genetic predisposition plays a role. Age and certain metabolic diseases are further risk factors that cannot be controlled.

In addition to a high-calorie diet and lack of exercise, the risk factors that can be controlled include, for example, persistent stress and socio-economic factors such as a low level of education and low income.

 

Obesity is diagnosed on the basis of the body mass index (BMI). This unit of measurement puts body weight in relation to height. A BMI of 25 kg/m² or higher is considered overweight while a BMI of 30 kg/m² or higher is considered obesity.

Good to know:

Formula for calculating the body mass index (BMI):

BMI = body weight (kg) / height squared (m²)

The distribution of body fat also has an impact on health risk. Visceral fat in particular, which accumulates around the organs in the abdomen, is associated with a high health risk. This can be determined using the waist circumference.

Find detailed information on the risk factors and diagnosis of obesity here.
 

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5. How is obesity treated?

As a chronic disease, obesity requires lifelong, individually tailored treatment. The therapy aims at reducing body weight in the long term, preventing the development of concomitant and secondary diseases and improving quality of life.

The multimodal basic therapy for obesity is based on a combination of dietary changes, more exercise and behavioral therapy. If this does not achieve sufficient weight reduction, formula diets or medication can be used as support. In Germany, there are three approved active substance groups: lipase inhibitors (orlistat), GLP-1 receptor agonists (liraglutide and semaglutide) and dual receptor agonists (tirzepatide).

In some cases, surgery may be another treatment option. Various methods are available for weight-loss surgery, often also referred to as bariatric or metabolic surgery, such as sleeve gastrectomy and gastric bypass.

Since 2020, digital health applications (digitale Gesundheitsanwendungen, DiGAs; apps on prescription) have also been approved as a supplement to obesity treatment.

Find more information about the different approaches to treating obesity and how these can help to reduce body weight and stabilize it in the long term here.
 

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6. How widespread is obesity in Germany?

The incidence of overweight and obesity has risen in recent decades. In Germany, more than half of adults are overweight. Of these, around a quarter have a BMI of 30 kg/m² or higher and are considered obese.

While the overall incidence of overweight and obesity increases with age, more and more children and adolescents also have an increased body weight.

Find more information on the prevalence of obesity in Germany here.
 

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Bundesinstitut für Arzneimittel und Medizinprodukte: Verzeichnis für digitale Gesundheitsanwendungen (DiGA). (Letzter Abruf: 17.02.2025)
Bundesministerium für Gesundheit. Ratgeber zur Prävention und Gesundheitsförderung. 2016. (Letzter Abruf: 17.02.2025)
Deutsche Adipositas-Gesellschaft et al.: S3-Leitlinie Adipositas - Prävention und Therapie. Version 5.0. 2024
Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie: S3-Leitlinie Chirurgie der Adipositas und metabolischer Erkrankungen. Version 2.3. 2018 (Gültigkeit abgelaufen, in Überarbeitung)
Deutsche Gesellschaft für Ernährung (Hrsg.): 15. DGE-Ernährungsbericht. Bonn. 2024
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Guh, D. P. et al.: The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis. In: BMC Public Health, 2009, 9: 88
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Robert Koch-Institut: KiGGS Welle 2 – Erste Ergebnisse aus Querschnitt- und Kohortenanalysen. In: Journal of Health Monitoring, 2018, 3: 1-151
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As of: 17.02.2025