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A collaborative effort by Helmholtz Munich, the German Diabetes Center, and the German Center for Diabetes Research

Obesity: How high is my risk and how is it diagnosed?

Scientific support: Prof. Dr. Hans Hauner

Obesity means that more energy is taken in with food than is consumed through metabolic processes and physical activity. Even a slight imbalance between energy intake and consumption over a longer period can lead to overweight or severe overweight (obesity). An unhealthy lifestyle, i.e., a diet that exceeds one’s own needs and a lack of exercise, therefore contributes significantly to an unbalanced energy balance. In addition to personal lifestyle, genetic and psychological aspects as well as social factors such as family environment, residential area, income, education and occupation also play an important role.

Body weight is categorized on the basis of the body mass index (BMI). The distribution of body weight is also crucial, as it strongly influences the risk of concomitant and secondary diseases.



1. What increases the risk of obesity?

A number of factors can promote obesity:

  • Frequent cases of obesity in the family (genetic predisposition)
  • Unhealthy lifestyle:
    • Lack of exercise
    • Large portions of food and constant availability of energy-rich foods
    • Food having a high calorie content
    • Few vegetables, fruit and wholegrain products
  • Stress, lack of sleep and depressive illnesses
  • Eating disorders, for example “binge eating”
  • Pregnancy
  • Abstaining from smoking
  • Metabolic diseases, for example, hypothyroidism or Cushing’s syndrome
  • Medications that affect body weight, such as cortisone and some medications for depression, high blood pressure or diabetes
  • An unfavorable social environment
  • Socio-economic factors such as low income and low level of education

 


2. What is the role of genetics?

Genetic predisposition has a major influence on a person’s individual risk of developing obesity in the course of his or her life. Various studies suggest that genes contribute to the development of obesity by 30 to 70 percent. For example, genes influence how much food a person eats and how it is metabolized. Observational studies of twins growing up separately or adopted children show that the body weight of children is more likely to be determined by their genetic predisposition than by the environment in which they grow up.

Obesity results from a complex interplay of genetic predisposition and environmental factors. However, a genetic predisposition does not necessarily lead to obesity. Body weight can be significantly influenced by the lifestyle that a person chooses.


3. What is the significance of one’s own lifestyle?

Today’s widespread lifestyle of excessive energy intake combined with a lack of physical activity is considered to be the main cause of overweight and obesity. Your body weight is significantly influenced by your own behavior in terms of diet and exercise as well as the quality of your sleep and how you deal with stress.

Read here what a healthy lifestyle can look like and how you can motivate yourself to eat healthily and get enough exercise in the long term.

 

Mental illnesses such as eating disorders can also be a trigger for overweight and obesity. A binge eating disorder (BED) is characterized by repeated episodes of uncontrollable eating. Unlike bulimia (compulsive overeating followed by vomiting), people with binge eating disorder do not vomit to counteract weight gain.

In night eating syndrome, cravings at night lead to uncontrollable eating.

Good to know:

Eating disorders such as binge eating disorder or night eating syndrome can be a risk factor for weight gain and obesity. People with obesity are more likely to develop depressive disorders. Depression can contribute to overeating.

Find more information on the concomitant and secondary diseases of obesity here.


4. What is the influence of external living conditions?

In recent decades, the number of people with obesity has risen sharply in industrialized nations. Researchers think this can mainly be attributed to modern lifestyle habits. In a changing world of work, sedentary and less physically strenuous activities are increasingly being performed. Digitalization and the use of smartphones and streaming services also encourage sedentary behavior in leisure time – both among adults and children.

At the same time, the supply of industrially produced, highly processed foods has multiplied over the last 50 years. These products are often low in fiber but high in sugar and fat. Soft drinks with a high sugar content, fast food and snacks are available everywhere and can be consumed quickly.

Studies show that obesity is more widespread in population groups with a low level of education and low social status. On the one hand, this is due to economic factors: Foods such as fruit, vegetables and wholegrain products, which contribute to a healthy diet, are often more expensive and more difficult to access for people on a low income. Highly processed, energy-dense products such as snacks and fast food, in contrast, are often inexpensive and available everywhere. In addition, health literacy and therefore knowledge about a healthy lifestyle is lower in social classes with a lower level of education. As a result, less attention is usually paid to healthy eating.

The living environment also influences people’s motional behavior. Especially in cities, socially disadvantaged areas often have fewer green spaces, bikeways, playgrounds or sports clubs. In addition, there may be factors such as increased stress due to noise load, air pollution or social isolation.


5. How do stress and depression affect body weight?

Constant stress increases the risk of developing overweight and obesity. In addition, obesity itself can trigger stress due to the psychosocial burdens that can accompany the disease. People with obesity often feel stigmatized and discriminated against by their environment and often have a negative body image of themselves. Stress and obesity can therefore reinforce each other in a kind of vicious circle.

Chronic stress and depression destabilize the hormonal balance and particularly lead to an increased release of cortisol. This messenger substance plays an important role in appetite regulation. Under stress or in depressive phases, many people eat more and, above all, higher-calorie foods. This increases the risk of overweight and obesity. Depression is often accompanied by listlessness and low physical activity, which in turn reduces energy consumption.

Medication for the treatment of depression can also increase appetite. Weight gain as a side effect is mainly observed with tricyclic antidepressants (e.g., amitriptyline), tetracyclic antidepressants (e.g., mirtazapine) and some serotonin reuptake inhibitors (e.g., escitalopram).

Good to know:

Some drugs can cause weight gain as a side effect. Examples include certain drugs for depression, psychosis, epilepsy, diabetes, glucocorticoids (cortisone) and certain contraceptives.


6. How is obesity diagnosed?

A simple unit of measurement for estimating body weight in relation to height is the body mass index, or BMI for short. The BMI is calculated by dividing body weight (in kg) by height squared (in m²).

According to the World Health Organization (WHO), adults with a BMI between 18.5 and 24.9 kg/m² are considered to be of normal weight. Overweight is defined as a BMI of 25 kg/m² or higher. Obesity begins at a body mass index of 30 kg/m². A distinction is made between three different degrees of obesity.

Formula for calculating the body mass index (BMI):

BMI = body weight (kg) / height squared (m²)

The higher the BMI, the higher the health risk for other diseases.

Classification

Body mass index (BMI) [kg/m²]

Risk of secondary diseases

Underweight

below 18.5

Low

Normal weight

18.5 to 24.9

Average

Overweight

25 and higher

 

Pre-obesity

25 to 29.9

Slightly increased

Obesity

30 and higher

 

     1st degree

30 to 34.9

Increased

     2nd degree

35 to 39.9

High

     3rd degree

40 and higher

Very high

 

Although the BMI is used worldwide as a measure to define obesity, it has only limited significance for the health risks caused by obesity. The BMI does not differentiate between body fat, bone or muscle mass and does not allow any conclusions to be drawn about the distribution of fat tissue. For example, well-trained athletes with a high muscle mass have a higher BMI. Factors such as age, gender and ethnicity can also influence the BMI.

Weight is not the only decisive factor in the risk of developing obesity-related secondary diseases. The distribution of body fat plays a greater role. Visceral fat in particular, which accumulates deep in the abdomen around the internal organs, is associated with a high health risk. Too much visceral fat can impair organ functions and promote inflammatory processes. This increases the risk of type 2 diabetes and cardiovascular disease, for example.

The amount of abdominal fat can be assessed by measuring the waist circumference. The waist circumference is measured midway between the last rib and the highest point of the lateral pelvic bone, i.e., the iliac crest.

There is an increased health risk

  • for women with a waist circumference of 80 centimeters or more,
  • for men with a waist circumference of 94 centimeters or more.

A waist circumference of more than 88 centimeters (for women) or 102 centimeters (for men) is indicative of a significantly increased health risk and abdominal obesity!

 

Other key figures that can be used to diagnose obesity are:

  • Waist-to-hip ratio (WHR): The WHR describes the ratio of waist circumference to hip circumference. Abdominal obesity is defined by the WHO as a WHR of more than 0.90 in men and 0.85 in women.
  • Waist-to-height ratio (WHtR): This value describes the ratio of waist circumference to height. For the diagnosis of abdominal obesity, a threshold value of 0.5 applies for men and women. From the age of 50, this value rises to 0.6.

Good to know:

Due to the limited informative value of the BMI and the high relevance of body fat distribution for health risk, an international commission called for a redesign of obesity diagnostics at the beginning of 2025. The experts recommend determining the waist circumference, the waist-to-hip ratio (WHR) or the waist-to-height ratio (WHtR) in addition to the BMI or carrying out direct measurements of body fat to establish a diagnosis.

Measurement of body composition

Various methods are available for determining body composition. In bioelectrical impedance analysis (BIA), a weak electric current is passed through the body using electrodes. Based on the electrical resistance that can be measured, conclusions can be drawn about the water or fat content of the body. Muscles contain more water than body fat and thus increase electrical conductivity.

Body composition tests should be used if muscle wasting, which may be associated with obesity, is suspected. If muscle mass is reduced, experts speak of sarcopenic obesity.

During weight loss, bone density may decrease – especially in older people. If this is suspected, a bone density measurement is therefore recommended to accompany treatment. As a standard, this measurement is carried out using dual energy x-rayabsorptiometry (DXA).

Determining the state of health

In addition to determining the body weight, the BMI and the waist circumference, the attending physician should also carefully examine the patient’s general state of health before starting obesity treatment. The following aspects should be determined and taken into account in the subsequent treatment plan:

  • Existing concomitant and secondary diseases:
    Does the patient already have concomitant and secondary illnesses such as cardiovascular disease, diabetes, joint problems, cognitive impairments (e.g., dementia) or psychological stress?
  • Existing risk factors for cardiovascular and metabolic diseases:
    Determination of blood pressure, blood sugar and blood lipid levels.
  • Previous nutrition and exercise behavior:
    When, how often, how much and for what reason does the patient eat? How is the patient’s physical activity and physical fitness?
  • Presence of an eating disorder:
    Does the patient have a binge eating disorder (BES) or night eating syndrome?
  • Clarification of medical causes:
    Medical clarification when hormone-related metabolic disorders are suspected, for example hypothyroidism or Cushing’s syndrome, which may be the cause of obesity.

 

During obesity treatment, the relative weight loss (RWL) should be determined regularly in addition to body weight and BMI. A weight reduction of at least 5 percent of the initial weight should be aimed at because it may already have a positive effect on health, for example on blood lipid levels and existing diabetes.


7. When are children and adolescents considered obese?

An unhealthy lifestyle – a high-calorie diet and too little exercise – can lead to overweight and obesity even in children and adolescents. If obesity is already present in childhood, the risk of other diseases also increases. In addition, overweight and obese children are more at risk of being bullied at school and suffering from depression.

As with adults, the body mass index (BMI) is also used as a unit of measurement to define overweight and obesity in children and adolescents. However, due to growth, age and gender play a decisive role in the assessment of the BMI. Against this background, age- and gender-specific reference values, known as BMI percentiles, are used to estimate body weight in relation to height for children and adolescents. The calculation of these percentiles for the BMI was based on the height and body weight data of more than 34,000 girls and boys aged 0 to 18 from different regions of Germany.

Taking age and gender into account, overweight in children and adolescents is defined as a BMI that exceeds the 90th percentile. This means that 90 in 100 children of the same sex and age have a lower BMI. If the BMI exceeds the 97th percentile, children and adolescents are considered obese.

Find more information on obesity in children and adolescents on the “Preventing Obesity” information portal of the Federal Institute of Public Health (Link in German).

The clever.gesund portal from Helmholtz Munich, which is sponsored by the AOK Bayern health insurance fund, is aimed directly at young people and provides information about a healthy lifestyle (Link in German).

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As of: 17.02.2025